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Contraindicated (one)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with strong CYP3A4 inducers; these medicines lower exposure to vandetanib by as much as forty%.pentobarbital will minimize the extent or effect of alosetron by impacting hepat

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